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Updated: 4 hours 58 min ago

New model identifies drugs that shouldn’t be taken together

Tue, 02/20/2024 - 11:00
Any drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this process, but for many drugs, it’s unknown which of those transporters they use to exit the digestive tract.

Identifying the transporters used by specific drugs could help to improve patient treatment because if two drugs rely on the same transporter, they can interfere with each other and should not be prescribed together.

Acquisition of Icosavax completed

Mon, 02/19/2024 - 11:00
AstraZeneca announced today the successful completion of the acquisition of Icosavax, Inc., a US-based clinical-stage biopharmaceutical company focused on developing differentiated, high-potential vaccines using an innovative, protein virus-like particle (VLP) platform. As a result of the acquisition, Icosavax has become a subsidiary of AstraZeneca, with operations in Seattle, US.

UIC research helps create new antibiotic that evades bacterial resistance

Fri, 02/16/2024 - 11:00
Scientists at the University of Illinois Chicago and Harvard University have developed an antibiotic that could give medicine a new weapon to fight drug-resistant bacteria and the diseases they cause.

The antibiotic, cresomycin, described in Science, effectively suppresses pathogenic bacteria that have become resistant to many commonly prescribed antimicrobial drugs.

First patient randomized in AskBio Phase II gene therapy trial for congestive heart failure

Thu, 02/15/2024 - 11:00
Bayer AG and Asklepios BioPharmaceutical, Inc. (AskBio), a gene therapy company wholly owned and independently operated as a subsidiary of Bayer AG, announced that the first patient has been randomized in GenePHIT (Gene PHosphatase Inhibition Therapy), a Phase II trial of AB-1002 (also known as NAN-101) for the treatment of congestive heart failure (CHF).

Clinical trial shows rheumatoid arthritis drug could prevent disease

Wed, 02/14/2024 - 11:00
A drug used to treat rheumatoid arthritis could also prevent the disease in individuals deemed to be at risk.

Results from a Phase 2b clinical trial, published in The Lancet by researchers led by King's College London, provides hope for arthritis sufferers after it was shown that the biologic drug abatacept reduces progression to this agonising chronic inflammatory disease.

Cleveland Clinic research reveals unique tumor-related bacteria tied to young-onset colorectal cancer

Tue, 02/13/2024 - 11:00
New research from global health system Cleveland Clinic has mapped changes in tumor-related bacteria to uncover potential new strategies to combat the rise of young-onset colorectal cancer (CRC) in people under the age of 50.

The research reveals differences in tumor-related bacteria associated with young-onset colorectal cancer.

Vaccine shows promise against CMV, a virus that causes birth defects

Mon, 02/12/2024 - 11:00
An experimental mRNA vaccine against human cytomegalovirus (CMV), a common virus that can infect babies during pregnancy, elicited some of the most promising immune responses to date of any CMV vaccine candidate, according to a study by Weill Cornell Medicine investigators.

Using cancer's strength to fight against it

Fri, 02/09/2024 - 11:00
Scientists at the UC San Francisco (UCSF) and Northwestern Medicine may have found a way around the limitations of engineered T cells by borrowing a few tricks from cancer itself.

By studying mutations in malignant T cells that cause lymphoma, they zeroed in on one that imparted exceptional potency to engineered T cells. Inserting a gene encoding this unique mutation into normal human T cells made them more than 100 times more potent at killing cancer cells without any signs of becoming toxic.

Chapman scientists code ChatGPT to design new medicine

Thu, 02/08/2024 - 11:00
Generative artificial intelligence platforms, from ChatGPT to Midjourney, grabbed headlines in 2023. But GenAI can do more than create collaged images and help write emails - it can also design new drugs to treat disease.

Today, scientists use advanced technology to design new synthetic drug compounds with the right properties and characteristics, also known as "de novo drug design." However, current methods can be labor-, time-, and cost-intensive.

Vividion Therapeutics starts Phase I clinical trial in advanced solid and hematologic tumors with oral STAT3 inhibitor

Wed, 02/07/2024 - 11:00
Vividion Therapeutics, Inc. (Vividion), announced that it has initiated dosing of patients in a Phase I clinical trial evaluating VVD-130850, an investigational oral STAT3 inhibitor for the treatment of advanced solid and hematologic tumors. Vividion is a biopharmaceutical company, and a wholly owned and independently operated subsidiary of Bayer AG,

MSU researchers find early, promising glioblastoma treatment

Tue, 02/06/2024 - 11:00
A team of Michigan State University scientists has unveiled a potential game-changer in the fight against glioblastoma, the most common and currently incurable form of brain cancer.

A team of Michigan State University scientists has unveiled a potential game-changer in the fight against glioblastoma, the most common and currently incurable form of brain cancer.

The American Cancer Society and Pfizer announce a $15 million, three-year initiative to bridge the gap in cancer care disparities

Mon, 02/05/2024 - 11:00
The American Cancer Society (ACS) and Pfizer Inc. (NYE: PFE) today announced the launch of "Change the Odds: Uniting to Improve Cancer Outcomes™," a three-year initiative to bridge the gap in cancer care disparities. Through $15 million in funding from Pfizer, the initiative aims to improve health outcomes in medically underrepresented communities across the United States by enhancing awareness of and access to cancer screenings, clinical trial opportunities, and patient support and comprehensive navigation.

Cheating death: How cancer cells escape

Fri, 02/02/2024 - 11:00
Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.

US prescription drug prices are 2.78 times those in other wealthy nations

Thu, 02/01/2024 - 11:00
Prescription drug prices in the U.S. are significantly higher than in other nations, with prices in the U.S. averaging 2.78 times those seen in 33 other nations, according to a new RAND report.

The gap between prices in the U.S. and other countries is even larger for brand-named drugs, with U.S. prices averaging 4.22 times those in comparison nations.

Nanotechnology-based CRISPR/Cas9 delivery system for genome editing in cancer treatment

Wed, 01/31/2024 - 11:00
This review is designed by Professor Changyang Gong and written by his PhD student Shiyao Zhou. At the beginning, they elaborated the mechanism of CRISPR/Cas9 system. CRISPR/Cas9 system consists of Cas9 protein and single stranded directing RNA (sgRNA). In the presence of protospacer adjacent motif (PAM), sgRNA accurately leads the Cas9 endonuclease to the target regions, where it causes DNA double strand breaks (DSBs), resulting in site‐specific genomic change.

Up to three daily servings of kimchi may lower men's obesity risk

Tue, 01/30/2024 - 11:00
Eating up to three daily servings of the Korean classic, kimchi, may lower men's overall risk of obesity, while radish kimchi is linked to a lower prevalence of midriff bulge in both sexes, finds research published in the open access journal BMJ Open.

Kimchi is made by salting and fermenting vegetables with various flavourings and seasonings, such as onion, garlic, and fish sauce.

New technology makes cancer easier for immune system to find and destroy

Mon, 01/29/2024 - 11:00
A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer.

Major histocompatibility complex (MHC) class I molecules are an immune complex present on the surface of all cells in humans. MHC class I molecules are a prerequisite for the immune system to recognize and eliminate cancer.

'Cancer-cooling' protein puts bowel cancer on ice

Fri, 01/26/2024 - 11:00
A protein in the immune system can be manipulated to help overcome bowel cancer, according to new research from The Australian National University (ANU).

Bowel cancer claims more than 100 lives in Australia each week, yet around 90 per cent of cases can be successfully treated if detected early.

Autonomous synthesis robot uses AI to speed up chemical discovery

Thu, 01/25/2024 - 11:00
Chemists of the University of Amsterdam (UvA) have developed an autonomous chemical synthesis robot with an integrated AI-driven machine learning unit. Dubbed 'RoboChem', the benchtop device can outperform a human chemist in terms of speed and accuracy while also displaying a high level of ingenuity. As the first of its kind, it could significantly accelerate chemical discovery of molecules for pharmaceutical and many other applications.

Could two drugs be better than one for treating prostate cancer?

Wed, 01/24/2024 - 11:00
Combining testosterone-blocking drugs in patients with prostate cancer relapse prevents the spread of cancer better than treatment with a single drug, a multi-institution, Phase 3 clinical trial led by UC San Francisco researchers has found.

The approach can extend the time between debilitating drug treatments without prolonging the time it takes to recover from each treatment.